TLDR Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.
The study from 2008 examined the impact of metformin and rosiglitazone on glucose transporter 4 (GLUT4) mRNA expression in 35 women with polycystic ovary syndrome (PCOS), with 33 completing the trial. After 6 months of treatment, both drugs significantly increased GLUT4 mRNA expression in adipose tissue, with rosiglitazone showing a more pronounced effect. Improvements were also seen in insulin resistance, as indicated by the Homeostasis Model Assessment (HOMAIR) score, menstrual bleeding frequency, and serum total testosterone levels. The study concluded that both metformin and rosiglitazone enhance clinical, hormonal, and metabolic parameters in PCOS patients, with neither drug proving superior. Further research was suggested to explore the mechanisms of these treatments and their efficacy in different patient subgroups.
192 citations,
September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.
1947 citations,
September 1995 in “New England journal of medicine/The New England journal of medicine” PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.
883 citations,
August 2016 in “Nature Reviews Disease Primers” Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.
20 citations,
October 2008 in “European journal of endocrinology” Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.
31 citations,
February 2021 in “Nutrients” Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.
19 citations,
March 2007 in “Journal of diabetes science and technology” Rosiglitazone may be better than metformin for insulin resistance in PCOS, but more research is needed on certain biomarkers.
October 2023 in “Frontiers in endocrinology” Effective PCOS treatments require targeting specific signaling pathways.
