Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

The document summarizes a systematic review and meta-analysis that evaluated the impact of curcumin on glycemic control and lipid profiles in 168 patients with Polycystic Ovary Syndrome (PCOS). The analysis, which included three randomized controlled trials, found that curcumin significantly improved fasting glucose, fasting insulin, HOMA-IR, QUICKI, HDL, and total cholesterol levels, but did not show significant effects on LDL and triglycerides. The trial sequential analysis confirmed the conclusiveness of the results for fasting glucose, fasting insulin, HOMA-IR, QUICKI, and total cholesterol. Despite these positive findings, the study acknowledged limitations such as the small number of studies, variations in curcumin dosage and treatment duration, and lack of information on curcumin preparation. The effects of curcumin on hyperandrogenism in PCOS were not assessed due to insufficient data. The study concluded that curcumin may be beneficial for glycemic control and lipid metabolism in PCOS patients, but further research is necessary to explore its full potential, including its impact on hyperandrogenism.