Decreased Lipin 1β Expression in Visceral Adipose Tissue Is Associated with Insulin Resistance in Polycystic Ovary Syndrome

In a study from December 2008, researchers examined the expression of lipin 1β in 85 patients with polycystic ovary syndrome (PCOS) and 44 controls, finding that lipin 1β levels were significantly lower in the adipose tissue of PCOS patients. This decrease was associated with insulin resistance (IR), a common issue in PCOS that increases the risk of type 2 diabetes and cardiovascular disease. The study showed that lower lipin 1β expression in visceral adipose tissue was linked to higher body mass index (BMI), waist circumference, and HOMA-IR, and lower high-density lipoprotein cholesterol. These findings suggest that lipin 1β may play a role in the development of IR in PCOS.