Hair Growth-Promoting Effect of Hydrangea Serrata Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study

September 2024 in “ International Journal of Molecular Sciences ”

Taesun Park, Hyunjae Kim, Hye Shin Ahn, Changseon Na, Yu‐Kyong Shin

Hydrangea serrata extract hydrangenol 5α-reductase dermal papilla cells hair growth-related genes anti-inflammatory anti-androgenic C57BL/6 mice human skin organoids nutraceutical WHS 5-alpha-reductase hair growth genes anti-inflammatory properties anti-androgen properties hair health supplement

Studysummary This study found that hot water extract of Hydrangea serrata leaf and hydrangenol promoted hair growth by enhancing 5α-reductase inhibitory activity, stimulating dermal papilla cell growth, and exhibiting anti-inflammatory and anti-androgenic effects in cell cultures, mice, and human skin organoid models.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explores the hair growth-promoting effects of Hydrangea serrata extract (WHS) and its active component, hydrangenol, using in vitro and in vivo models, including C57BL/6 mice and human skin organoids. WHS and hydrangenol were found to inhibit 5α-reductase activity, stimulate dermal papilla cell growth, and enhance the expression of hair growth-related genes. They also exhibited anti-inflammatory and anti-androgenic properties. In mice, WHS improved hair growth parameters over 3 weeks, and in human skin organoids, it stimulated hair formation. These findings suggest WHS as a promising nutraceutical for hair health, although further clinical trials are needed to validate these results in humans.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

30 / 30 results

research Factors Associated With Early-Onset Androgenetic Alopecia: A Scoping Review

March 2024 in “PLOS ONE”

This review explores the risk factors, associated comorbidities, and psychological impacts of early-onset androgenetic alopecia, highlighting its complexity and potential implications for treatment response and overall health.

research Beta-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

February 2024 in “Molecules/Molecules online/Molecules annual”

In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.

research Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

In this study, DHT was found to inhibit hair growth in mice by decreasing IGF-I production in dermal papillae through reduced sensory neuron stimulation.

research Hair Lipid Structure: Effect of Surfactants

2 citations , July 2023 in “Cosmetics”

In this study, researchers highlighted that while hair lipids are crucial for hair health and protection, surfactants in shampoos and conditioners can partially remove these lipids, potentially affecting hair structure, though the exact mechanisms remain poorly understood and require further investigation.

Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells

research Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells

3 citations , September 2022 in “Molecules”

This study found that Camellia seed cake extract may counteract DHT-induced effects in cultured dermal papilla cells, suggesting potential to prevent or alleviate androgenetic alopecia.

research The Hair Growth-Promoting Effect of Gardenia Florida Fruit Extract and Its Molecular Regulation

1 citations , September 2022 in “Evidence-based Complementary and Alternative Medicine”

In this study, Gardenia florida fruit extract promoted hair growth in vitro and in vivo by enhancing hair growth-promoting gene expression and increasing hair follicle number, size, and depth in mice.

research Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells

425 citations , June 2020 in “Nature”

Scientists created human skin with hair from stem cells, which could help treat hair loss and skin conditions.

research Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep

23 citations , May 2020 in “Cell Death and Disease”

This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.

An Asian Traditional Herbal Complex Containing Houttuynia Cordata Thunb, Perilla Frutescens Var. Acuta, and Green Tea Stimulates Hair Growth in Mice

research An Asian Traditional Herbal Complex Containing Houttuynia Cordata Thunb, Perilla Frutescens Var. Acuta, and Green Tea Stimulates Hair Growth in Mice

13 citations , December 2017 in “BMC Complementary and Alternative Medicine”

In this study, the herbal complex of Houttuynia cordata, Perilla frutescens var. acuta, and green tea promoted hair growth in C57BL/6 mice, enhancing regrowth and follicle development compared to controls.

research Hydrogen Peroxide (H2O2) Suppresses Hair Growth Through Downregulation of Beta-Catenin

13 citations , September 2017 in “Journal of Dermatological Science”

Hydrogen peroxide in hair dye can cause hair loss.

research Experimental and Early Investigational Drugs for Androgenetic Alopecia

11 citations , July 2017 in “Expert Opinion on Investigational Drugs”

This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.

research Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction

35 citations , January 2017 in “Journal of Dermatological Science”

This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.

research Changing the Shape of Hair with Keratin Peptides

47 citations , January 2017 in “RSC Advances”

Keratin peptides can change hair shape gently without harsh chemicals.

research Immunopotentiator from Pantoea Agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression

July 2016 in “PubMed”

This study revealed that IP-PA1, derived from Pantoea agglomerans, promoted hair growth in mice and increased certain growth factor expressions in human cell cultures, suggesting a unique mechanism compared to traditional hair growth treatments.

research Hot Water Extract of Oriental Melon Leaf Promotes Hair Growth and Prolongs Anagen Hair Cycle: In Vivo and In Vitro Evaluation

3 citations , April 2016 in “Food Science and Biotechnology”

This study found that Oriental melon leaf extracts promoted hair growth in a mouse model and cultured human hair follicles, suggesting potential use as a treatment for hair loss.

research Nanotechnology-Based Cosmetics for Hair Care

42 citations , July 2015 in “Cosmetics”

This review discusses the use of cosmetic nanocarriers to improve hair appearance and reports no new experimental results.

research Understanding Hair Loss Due to Air Pollution and the Approach to Management

7 citations , January 2015 in “Hair therapy & transplantation”

This review discusses the impact of air pollution on hair loss and sensitive scalp syndrome, evaluating possible causes and management strategies, but reports no new clinical results.

research Investigation of Oxidative Stress in Patients with Alopecia Areata and Its Relationship with Disease Severity, Duration, Recurrence, and Pattern

35 citations , December 2014 in “Clinical and experimental dermatology”

This study found that patients with alopecia areata had reduced erythrocyte SOD and GSH-Px activities and elevated plasma MDA levels, suggesting a potential role of oxidative stress in the disease's pathogenesis.

research Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

81 citations , June 2014 in “American Journal of Men's Health”

This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations , January 2012 in “British Journal of Dermatology”

This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.

research 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment

69 citations , December 2011 in “Journal of Ethnopharmacology”

This study found that Carthamus tinctorius exhibited the strongest 5α-reductase inhibitory and hair growth promoting activities among evaluated Thai herbs, suggesting potential for developing alternative hair loss treatments.

research TSH Is a Novel Neuroendocrine Regulator of Selected Keratins in the Human Hair Follicle

14 citations , June 2011 in “Journal of Dermatological Science”

TSH influences keratin expression in human hair follicles.

research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

185 citations , March 2011 in “The Journal of Sexual Medicine”

This study found that 94% of healthy men reported low libido and 92% reported erectile dysfunction as persistent sexual side effects after using finasteride for male pattern hair loss, with these effects lasting on average 40 months post-discontinuation.

research Chronological Aging of Human Hair Keratin Fibers

49 citations , April 2010 in “International Journal of Cosmetic Science”

This study details how very long human hair naturally ages, showing cuticle wear and internal fiber changes that may inform new hair care product designs.

research Oxidative Stress in Aging of Hair

126 citations , January 2009 in “International Journal of Trichology”

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.

research Hair Follicle-Specific Keratins And Their Diseases

138 citations , March 2007 in “Experimental cell research”

This review discusses hair keratins and hair follicle-specific epithelial keratins and their association with inherited hair disorders, reporting no new clinical results.

research Integral Lipid in Human Hair Follicle

30 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study discovered that the lipid in human hair follicles is mainly located in the hair cuticle and keratinized inner root sheath, distinct from sebaceous and epidermal lipids, suggesting a potential role as a "hair barrier.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.