Immunopotentiator from Pantoea Agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression

    July 2016 in “ PubMed ”
    Koji Wakame, Hiroshi Okawa, Ken-Ich Komatsu, Akifumi Nakata, Keisuke Sato, Hiroyuki Ingawa, Chie Kohchi, Takashi Nishizawa, Gen‐Ichiro Soma
    From the encyclopedia
    Vascular Endothelial Growth Factor →
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Adenosine →

    nucleoside used for hair regrowth stimulant properties

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    Studysummary This study revealed that IP-PA1, derived from Pantoea agglomerans, promoted hair growth in mice and increased certain growth factor expressions in human cell cultures, suggesting a unique mechanism compared to traditional hair growth treatments. Our plain-language summary of this paper — not a Tressless recommendation.
    In 2016, a study was conducted to investigate the hair growth-promoting effects of Immunopotentiator from Pantoea agglomerans 1 (IP-PA1). The compound was administered orally or applied to the skin of a C3H/HeN mouse, and hair growth was observed for 14 days. The results showed that IP-PA1 promoted hair growth in mice when given orally and significantly promoted hair growth when applied to the skin. Histopathological examinations further demonstrated hair elongation from dermal papilla cells. In a human dermal papilla cell culture system, significant fibroblast growth factor-7 (FGF-7) and vascular endothelial growth factor (VEGF) mRNA expressions were observed after IP-PA1 administration. The study concluded that the mechanism of gene expression by which IP-PA1 promotes hair growth is different from that of medicine and traditional hair tonics, such as minoxidil and adenosine.
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