Therapeutic And Clinical Potential Of Adipose-Derived Stem Cell Secretome For Skin Regeneration

    November 2025 in “ Cells ”
    Anna Sendera, Hubert Kubis, Anna Pałka, Agnieszka Banaś-Ząbczyk
    Studysummary This review presents evidence supporting the potential of adipose-derived stem cell secretome as a promising cell-free therapy for skin repair, emphasizing its application in wound healing, alopecia, skin rejuvenation, and inflammatory skin diseases.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 17

    1. Hair Growth Stimulated by Allogenic Adipose-Derived Stem Cells Supplemented with ATP in a Mouse Model of Dihydrotestosterone-Induced Androgenetic Alopecia Stem Cell Research & Therapy · 2025
    2. Mesenchymal Stem Cell Exosomes Enhance the Development of Hair Follicle to Ameliorate Androgenetic Alopecia World Journal of Stem Cells · 2025
    3. Hair Regeneration In Androgenetic Alopecia Using Secretome Of Adipose-Derived Stem Cells And Minoxidil: A Comparative Study Of Three Groups Archives of Dermatological Research · 2025
    4. Advances in Regenerative Medicine-Based Approaches for Skin Regeneration and Rejuvenation Frontiers in Bioengineering and Biotechnology · 2025
    5. Efficacy of Platelet-Rich Plasma Versus Mesotherapy with Recombinant Growth Factors and Stem Cell-Conditioned Media in Androgenetic Alopecia: A Retrospective Study Skin Appendage Disorders · 2024
    6. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    7. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging Clinical Cosmetic and Investigational Dermatology · 2023
    8. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    9. Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial Stem Cell Research & Therapy · 2023
    10. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021
    11. Comparison of Two ASC-Derived Therapeutics in an In Vitro Osteoarthritis Model: Secretome Versus Extracellular Vesicles Stem Cell Research & Therapy · 2020
    12. HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation International Journal of Molecular Sciences · 2019
    13. Stem Cell Secretome as a New Booster for Regenerative Medicine Bioscience trends · 2019
    14. Anti-Aging Properties of Conditioned Media of Epidermal Progenitor Cells Derived from Mesenchymal Stem Cells Dermatology and Therapy · 2018
    15. Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging International Journal of Molecular Sciences · 2017
    16. Alopecia Areata: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    17. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010