Comparison of Two ASC-Derived Therapeutics in an In Vitro Osteoarthritis Model: Secretome Versus Extracellular Vesicles

December 2020 in “ Stem Cell Research & Therapy ”

Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo, A.T. Brini

adipose-derived stem cell secretome extracellular vesicles matrix metalloproteinase PGE2 tissue inhibitors of MMPs COL10A1

Studysummary In this laboratory study, ASC-conditioned medium showed higher therapeutic potential than extracellular vesicles alone in reducing inflammation and catabolic activity in human chondrocytes with an osteoarthritis phenotype, highlighting its possible use in osteoarthritis management.

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