Hair Regeneration In Androgenetic Alopecia Using Secretome Of Adipose-Derived Stem Cells And Minoxidil: A Comparative Study Of Three Groups

    March 2025 in “ Archives of Dermatological Research ”
    Lili Legiawati, Irma Bernadette S. Sitohang, Shannaz Nadia Yusharyahya … Brigitta Cindy Lauren
    Studysummary This study observed that all treatment groups for androgenetic alopecia, using either minoxidil, adipose-derived stem cell secretome, or a combination, showed significant hair growth improvement, with the best results seen in the combination group by week 12, and minimal side effects noted mainly with minoxidil.
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    Research cited in this study 23

    1. Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis Psychology, Health & Medicine · 2023
    2. Combination of Adipose-Derived Stem Cell Conditioned Media and Minoxidil for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-Blind Clinical Trial Stem Cell Research & Therapy · 2023
    3. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    4. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    5. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    6. Androgenetic Alopecia: Clinical Features and Trichoscopy DOAJ (DOAJ: Directory of Open Access Journals) · 2022
    7. Hair Disorder in Dr. Cipto Mangunkusumo Cosmetic Dermatology and Venereology Outpatient Clinic of Jakarta, Indonesia: A Socio-Demographic and Clinical Evaluation Dermatology Reports · 2022
    8. Prevalence of Early-Onset Androgenetic Alopecia and Its Relation with Lifestyle and Dietary Habits Italian journal of dermatology and venereology · 2022
    9. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    10. Mesenchymal Stem Cell Secretome for Dermatology Application: A Review Clinical, Cosmetic and Investigational Dermatology · 2021
    11. Implications of Cigarette Smoking on Early-Onset Androgenetic Alopecia: A Cross-Sectional Study Journal of Cosmetic Dermatology · 2020
    12. Early-Onset Androgenetic Alopecia in China: A Descriptive Study of a Large Outpatient Cohort Journal of International Medical Research · 2020
    13. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium Dermatologic Surgery · 2019
    14. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    15. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    16. Frequency, Severity, and Related Factors of Androgenetic Alopecia in Dermatology Outpatient Clinic: Hospital-Based Cross-Sectional Study in Turkey Anais Brasileiros De Dermatologia · 2017
    17. Clinical Utility and Validity of Minoxidil Response Testing in Androgenetic Alopecia Dermatologic Therapy · 2014
    18. The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells The American Journal of Cosmetic Surgery · 2012
    19. Efficacy and Safety of 3% Minoxidil Versus Combined 3% Minoxidil / 0.1% Finasteride in Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Study PubMed · 2012
    20. A Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women Journal of The American Academy of Dermatology · 2011
    21. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    22. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    23. Male-Pattern Hair Loss in Norwegian Men: A Community-Based Study Dermatology · 2000

    Related research 7

    1. Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia Journal of Cosmetic Dermatology · 2023
    2. Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes Dermatologic Therapy · 2019
    3. The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years Italian journal of dermatology and venereology · 2018
    4. Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial 2010
    5. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    6. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    7. Topical Minoxidil Therapy and Hair Regrowth Archives of Dermatology · 1985