Hair Growth Stimulated by Allogenic Adipose-Derived Stem Cells Supplemented with ATP in a Mouse Model of Dihydrotestosterone-Induced Androgenetic Alopecia

June 2025 in “ Stem Cell Research & Therapy ”

Eduardo López Bran, L Perez, Patricia Esteban, María Luisa González-Morales

allogenic adipose-derived stem cells ATP dihydrotestosterone androgenetic alopecia ASCs DHT

TLDR Combining stem cells with ATP significantly boosts hair regrowth in mice with hair loss.

This study explored the impact of allogenic adipose-derived stem cells (ASCs) supplemented with ATP on hair regrowth in a mouse model of dihydrotestosterone-induced androgenetic alopecia. Using 200 mice, with 170 treated with DHT to simulate alopecia, the study found that ASCs combined with ATP significantly promoted hair regrowth. Male mice showed the most significant regrowth with low-dose ASCs and ATP, while female mice responded best to medium-dose ASCs with non-liposomal ATP. The results suggest that ATP can enhance the effectiveness of ASCs, offering a potential therapeutic approach for androgenetic alopecia.

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