Alopecia Areata

    November 2025 in “ Nature Reviews Disease Primers ”
    Benjamin Ungar, Yael Renert‐Yuval, Ncoza C. Dlova … Emma Guttman‐Yassky
    Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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    Research cited in this study 127

    1. Quality of Life, Psychosocial Difficulties and Bullying in Pediatric Patients with Alopecia Areata: A European Cross-Sectional Study British Journal of Dermatology · 2025
    2. Alopecia Areata in Skin of Color: Trichoscopic Analysis in Black/African American Patients Journal of Drugs in Dermatology · 2025
    3. Perceived Stigma Among Adults With Alopecia Areata In The United States The Journal of Dermatology · 2025
    4. Psychosocial Burden and the Impact of Illness Perceptions and Stigma on Quality of Life, Anxiety, and Depression in Alopecia Areata: Results from the Alopecia + Me Study British Journal of Dermatology · 2025
    5. Psychosocial and Occupational Burden on Caregivers of Adolescents With Alopecia Areata in Australia Australasian Journal of Dermatology · 2025
    6. Comparison of Dermatology Life Quality Index Scores in Adults and Adolescents With Alopecia Areata Dermatology and Therapy · 2025
    7. Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study Indian Dermatology Online Journal · 2025
    8. Patient-Reported Outcome Improvements Following Scalp Hair Regrowth Among Patients With Alopecia Areata: Analysis of the ALLEGRO-2b/3 Trial Journal of Dermatological Treatment · 2025
    9. The Role of Minoxidil in the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of Clinical Medicine · 2024
    10. Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata JAMA Dermatology · 2024
    11. Alopecia Areata Exhibits Cutaneous And Systemic OX40 Activation Across Atopic Backgrounds Allergy · 2024
    12. Lifetime Incidence and Healthcare Disparities in Alopecia Areata: A UK Population-Based Cohort Study British Journal of Dermatology · 2024
    13. Dupilumab Induces Hair Regrowth in Pediatric Alopecia Areata: A Real-World, Single-Center Observational Study Archives of Dermatological Research · 2024
    14. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    15. Dupilumab for the Treatment of Alopecia Areata in Pediatric Patients with Atopic Dermatitis: A Scoping Review Pediatric Dermatology · 2024
    16. Association Between Natural Hair Color, Race, And Alopecia Dermatology and Therapy · 2024
    17. Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study Skin Research and Technology · 2024
    18. Psychosocial and Mental Impact of Alopecia Areata: Analysis of the Danish Skin Cohort Journal of the European Academy of Dermatology and Venereology · 2024
    19. Improvement in Measures of Quality of Life and Symptoms of Anxiety and Depression in Patients with Severe Alopecia Areata Achieving Sustained Scalp Hair Regrowth with Baricitinib Dermatology and Therapy · 2024
    20. Epidemiology, Treatment Patterns, And Healthcare Resource Utilization Study Of Patients With Alopecia Areata In Taiwan's National Health Insurance Research Database Value in Health Regional Issues · 2024
    21. Health-Related Quality of Life of Adult and Adolescent Patients Living with Alopecia Areata in Australia Australasian Journal of Dermatology · 2024
    22. Evaluation of Quality of Life Scores and Family Impact Scales in Pediatric Patients with Alopecia Areata: A Cross-Sectional Cohort Study International Journal of Dermatology · 2024
    23. Ruxolitinib 1.5% Topical Cream for the Treatment of Pediatric Alopecia Areata Journal of Drugs in Dermatology · 2024
    24. Long-Term Efficacy and Safety of Baricitinib in Patients With Severe Alopecia Areata: 104-Week Results From BRAVE-AA1 and BRAVE-AA2 Journal of the European Academy of Dermatology and Venereology · 2024
    25. Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program American journal of clinical dermatology · 2024
    26. Mendelian Randomization Study Highlights Hypothyroidism as a Causal Determinant of Alopecia Areata Frontiers in endocrinology · 2024
    27. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    28. Alopecia Areata and Season of Onset: A Retrospective Study of 492 Cases Annals of Dermatology · 2024
    29. A Clinical Investigation of Early-Onset Alopecia Areata in Children: Onset Earlier Than 4 Years of Age Might Have a Better Short-Term Prognosis Experimental Dermatology · 2023
    30. Comorbid Conditions Associated With Alopecia Areata: A Systematic Review and Meta-Analysis American Journal of Clinical Dermatology · 2023
    31. Alopecia Areata Clinical Trial Enrollment and Retention Outcome Factors Among Underrepresented Ethnic and Racial Groups: A Cross-Sectional Study Journal of the American Academy of Dermatology · 2023
    32. Incidence and Prevalence of Alopecia Areata in the Australian Primary Care Setting: A Retrospective Analysis of Electronic Health Record Data Australasian Journal of Dermatology · 2023
    33. Treatment Response to Diphenylcyclopropenone in Patients with Alopecia Totalis/Universalis International Journal of Trichology · 2023
    34. Incidence Rates of Infections, Malignancies, Thromboembolism, and Cardiovascular Events in an Alopecia Areata Cohort from a US Claims Database Dermatology and therapy · 2023
    35. The Invisible Impact Of A Visible Disease: Psychosocial Impact Of Alopecia Areata Dermatology and Therapy · 2023
    36. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    37. Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population JAMA Dermatology · 2023
    38. Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
    39. Alopecia Areata in Underrepresented Groups: Preliminary Analysis of the All of Us Research Program Archives of Dermatological Research · 2023
    40. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    41. Quality of Life in Children and Adolescents With Alopecia Areata: A Systematic Review Journal of the European Academy of Dermatology and Venereology · 2023
    42. Nonscarring Alopecias 2023
    43. Alopecia Areata and Risk of Atopic and Autoimmune Conditions: Population-Based Cohort Study Clinical and Experimental Dermatology · 2022
    44. Beyond The Hot Comb: Updates In Epidemiology, Pathogenesis, And Treatment Of Central Centrifugal Cicatricial Alopecia From 2011 To 2021 American Journal of Clinical Dermatology · 2022
    45. Prevalence, Comorbidities, and Treatment Patterns of Japanese Patients with Alopecia Areata: A Descriptive Study Using Japan Medical Data Center Claims Database The Journal of Dermatology · 2022
    46. Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata Allergy · 2022
    47. Efficacy and Safety of Baricitinib in Adult Patients With Severe Alopecia Areata With or Without an Atopic Background From Two Randomized, Placebo-Controlled, Phase 3 Trials Journal of the American Academy of Dermatology · 2022
    48. Analysis of Alopecia Areata Surveys Suggests a Threshold for Improved Patient-Reported Outcomes British Journal of Dermatology · 2022
    49. Epidemiological, Clinical, and Trichoscopic Features of Syphilitic Alopecia: A Retrospective Analysis and Systematic Review Frontiers in Medicine · 2022
    50. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    51. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    52. The Epidemiology of Alopecia Areata: A Population-Based Cohort Study in UK Primary Care British Journal of Dermatology · 2021
    53. Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review Dermatology and Therapy · 2021
    54. Telogen Effluvium: A Review of the Science and Current Obstacles Journal of Dermatological Science · 2021
    55. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
    56. Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2020
    57. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    58. Efficacy of Antihistamines in Combination with Topical Corticosteroid and Superficial Cryotherapy for Treatment of Alopecia Areata: A Retrospective Cohort Study Journal of the American Academy of Dermatology · 2020
    59. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    60. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    61. Topical Calcipotriol vs Narrowband Ultraviolet B in Treatment of Alopecia Areata: A Randomized-Controlled Trial Archives of Dermatological Research · 2019
    62. All-Cause and Cause-Specific Mortality Risks Associated With Alopecia Areata JAMA dermatology · 2019
    63. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    64. Recalcitrant Alopecia Areata Responsive to Leflunomide and Anthralin—Potentially Undiscovered JAK/STAT Inhibitors? Pediatric dermatology · 2018
    65. Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata JAMA Dermatology · 2018
    66. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018
    67. An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation Journal of Allergy and Clinical Immunology · 2018
    68. Topical 2% Tofacitinib for Children with Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Journal of the American Academy of Dermatology · 2018
    69. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    70. Nail Changes in Alopecia Areata: An Update and Review International Journal of Dermatology · 2018
    71. Race and Alopecia Areata Amongst US Women Journal of Investigative Dermatology Symposium Proceedings · 2017
    72. Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata Journal of The American Academy of Dermatology · 2017
    73. Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients Journal of the American Academy of Dermatology · 2017
    74. Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata Journal of the American Academy of Dermatology · 2017
    75. Androgenetic Alopecia: A Review Endocrine · 2017
    76. Bilateral Half-Head Comparison of 1% Anthralin Ointment in Children with Alopecia Areata Pediatric dermatology · 2017
    77. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    78. Diagnosis and Management of Hair Loss in Children Current Opinion in Pediatrics · 2016
    79. All Hairstyles Are Not Created Equal: What the Dermatologist Needs to Know About Black Hairstyling Practices and the Risk of Traction Alopecia Journal of the American Academy of Dermatology · 2016
    80. Pulse Corticosteroid Therapy With Oral Dexamethasone for the Treatment of Adult Alopecia Totalis and Universalis Journal of the American Academy of Dermatology · 2016
    81. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    82. A Comparative Study of Oral Cyclosporine and Betamethasone Minipulse Therapy in the Treatment of Alopecia Areata Annals of dermatology/Annals of Dermatology · 2016
    83. Topical Ruxolitinib for the Treatment of Alopecia Universalis JAMA dermatology · 2015
    84. Quality of Life in Patients with Alopecia Areata: A Hospital-Based Cross-Sectional Study Journal of the European Academy of Dermatology and Venereology · 2015
    85. Retrospective Review of Diphencyprone in the Treatment of Alopecia Areata Clinical and Experimental Dermatology · 2015
    86. Alopecia: Children Are Not Just Little People Clinics in Dermatology · 2015
    87. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    88. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    89. Congenital Triangular Alopecia: Is It Always Confined to the Fronto-Temporal Region? Indian Journal of Dermatology, Venereology and Leprology · 2015
    90. Plasmacytoid Dendritic Cells in Alopecia Areata: Missing Link? Journal of the European Academy of Dermatology and Venereology · 2014
    91. Clinical Observations in Alopecia Areata: Implications and Hypotheses Australasian Journal of Dermatology · 2014
    92. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    93. Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children JAMA dermatology · 2013
    94. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    95. Pulse Corticosteroid Therapy for Alopecia Areata in Children: A Retrospective Study Dermatology · 2013
    96. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    97. Alopecia Areata Update Dermatologic Clinics · 2012
    98. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    99. Central Centrifugal Cicatricial Alopecia: An Approach to Diagnosis and Management International Journal of Dermatology · 2011
    100. Narrowband Ultraviolet B Phototherapy for Alopecia Areata Photodermatology Photoimmunology & Photomedicine · 2011
    101. Clinical Severity Does Not Reliably Predict Quality of Life in Women With Alopecia Areata, Telogen Effluvium, or Androgenic Alopecia Journal of The American Academy of Dermatology · 2011
    102. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    103. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    104. Bilateral Treatment for Alopecia Areata Pediatric dermatology · 2010
    105. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    106. Experimental Evaluation of Ebastine, a Second-Generation Antihistamine, as a Supportive Medication for Alopecia Areata Journal of Dermatological Science · 2010
    107. Type 1 Interferon Signature in the Scalp Lesions of Alopecia Areata British Journal of Dermatology · 2010
    108. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    109. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    110. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    111. Acute Diffuse And Total Alopecia: A New Subtype Of Alopecia Areata With A Favorable Prognosis Journal of The American Academy of Dermatology · 2008
    112. The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results Experimental dermatology · 2008
    113. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    114. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    115. Efficacy And Safety Of A New Clobetasol Propionate 0.05% Foam In Alopecia Areata: A Randomized, Double-Blind Placebo-Controlled Trial Journal of the European Academy of Dermatology and Venereology · 2006
    116. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005
    117. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis Journal of the American Academy of Dermatology · 2003
    118. Role of the Autoimmune Regulator (AIRE) Gene in Alopecia Areata: Strong Association of a Potentially Functional AIRE Polymorphism With Alopecia Universalis Tissue Antigens · 2002
    119. Acute Diffuse and Total Alopecia of the Female Scalp Dermatology · 2002
    120. Twice Weekly 5 mg Dexamethasone Oral Pulse in the Treatment of Extensive Alopecia Areata The Journal of Dermatology · 1999
    121. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    122. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    123. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994
    124. Failure of Passive Transfer of Serum From Patients With Alopecia Areata and Alopecia Universalis to Inhibit Hair Growth in Transplants of Human Scalp Skin Grafted Onto Nude Mice British Journal of Dermatology · 1992
    125. Hair Anatomy for the Clinician Journal of The American Academy of Dermatology · 1991
    126. Juvenile Versus Maturity-Onset Alopecia Areata: A Comparative Retrospective Clinical Study Clinical and Experimental Dermatology · 1989
    127. Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata Journal of The American Academy of Dermatology · 1987