Baricitinib Withdrawal and Retreatment in Patients With Severe Alopecia Areata

August 2024 in “ JAMA Dermatology ”

Lucy Liu, Justin Ko, Oh Sang Kwon, Sergio Vañó‐Galván, Bianca Maria Piraccini, Yves Dutronc, Guanglei Yu, Chunyuan Liu, Najwa Somani, Susan Ball, Natasha Atanaskova Mesinkovska

baricitinib alopecia areata placebo hair regrowth BRAVE-AA1 trial

TLDR Continuous baricitinib is needed to keep hair regrowth in severe alopecia areata.

The BRAVE-AA1 trial investigated the effects of baricitinib withdrawal and retreatment in 654 adults with severe alopecia areata. After 1 year of treatment, patients who responded were either continued on baricitinib or switched to a placebo. By week 152, 80% of those switched to placebo lost their hair regrowth benefits, compared to only 7% who continued baricitinib. Upon retreatment, 63% of patients on 2 mg and 87.5% on 4 mg regained their hair regrowth. The study concludes that continuous baricitinib therapy is necessary to maintain hair regrowth in severe alopecia areata.

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Research cited in this study

8 / 8 results

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community Article of all potential future cures

in Treatment 25 upvotes 7 months ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

community Lilly to seek first approval of an autoimmune drug for hair loss

in Research/Science 20 upvotes 4 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 3 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 2 years ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

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