TLDR Continuous baricitinib is needed to keep hair regrowth in severe alopecia areata.
The BRAVE-AA1 trial investigated the effects of baricitinib withdrawal and retreatment in 654 adults with severe alopecia areata. After 1 year of treatment, patients who responded were either continued on baricitinib or switched to a placebo. By week 152, 80% of those switched to placebo lost their hair regrowth benefits, compared to only 7% who continued baricitinib. Upon retreatment, 63% of patients on 2 mg and 87.5% on 4 mg regained their hair regrowth. The study concludes that continuous baricitinib therapy is necessary to maintain hair regrowth in severe alopecia areata.
1 citations
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October 2023 in “Dermatology and therapy” Some treatments for severe hair loss work but often have side effects, with baricitinib showing the most promise.
6 citations
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May 2023 in “Drugs” Baricitinib helps regrow hair in adults with severe alopecia better than a placebo and is approved for treatment, but long-term effects are still unknown.
20 citations
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March 2023 in “American Journal of Clinical Dermatology” Baricitinib improved severe hair loss in adults over 52 weeks and was safe to use.
148 citations
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March 2022 in “The New England Journal of Medicine” Baricitinib was effective in treating alopecia areata in two major trials.
20 citations
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December 2021 in “Journal of the American Academy of Dermatology” Continuous treatment with ritlecitinib and brepocitinib is needed to maintain hair regrowth in alopecia areata.
421 citations
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April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
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December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
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November 2018 in “JAAD case reports” Alopecia areata can sometimes appear as a straight line of hair loss instead of round patches.
May 2018 in “Journal of cosmetology & trichology” Combining platelet-rich plasma therapy with prostaglandin-F eye drops can significantly regrow hair in alopecia universalis.
