All-Cause and Cause-Specific Mortality Risks Associated With Alopecia Areata

    May 2019 in “ JAMA dermatology
    Solam Lee, Young Bin Lee, Beom Jun Kim, Sejin Bae, Won‐Soo Lee
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    Studysummary This study found that patients with alopecia areata had an increased risk of mortality from self-harm, psychiatric diseases, and lung cancer compared to the general population.
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    The retrospective cohort study, using data from the National Health Insurance Service database and National Death Registry of Korea, included 73,107 patients with alopecia areata and 731,070 age- and sex-matched controls to investigate all-cause and cause-specific mortality risks over a 10-year period. The study found no significant difference in all-cause mortality risk between patients with alopecia areata and controls. However, there was a higher mortality risk associated with intentional self-harm and psychiatric diseases in the alopecia areata group, especially among adults aged 35 years or younger and those with alopecia totalis/universalis. Additionally, patients with alopecia totalis/universalis had a higher mortality risk from lung cancer, while mortality associated with diabetes mellitus was significantly lower in the alopecia areata group. The study suggests that clinicians should focus on the emotional and psychological well-being of patients with alopecia areata to improve outcomes.
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