Improvement in Measures of Quality of Life and Symptoms of Anxiety and Depression in Patients with Severe Alopecia Areata Achieving Sustained Scalp Hair Regrowth with Baricitinib

June 2024 in “ Dermatology and Therapy ”

Brittany G. Craiglow, Yang Won Lee, Sergio Vañó‐Galván, Alexander Egeberg, Yves Dutronc, Frédérick Durand, Evangeline Pierce, Guanglei Yu, Yun-Fei Chen, Arash Mostaghimi

baricitinib alopecia areata scalp hair regrowth BRAVE-AA phase III trials

TLDR Baricitinib improves quality of life and reduces anxiety and depression in severe alopecia areata patients with hair regrowth.

The study examined the impact of baricitinib on health-related quality of life (HRQoL) and symptoms of anxiety and depression in patients with severe alopecia areata (AA) over 104 weeks. Patients who achieved sustained scalp hair regrowth during the BRAVE-AA phase III trials reported significant improvements in HRQoL and reductions in anxiety and depression symptoms, highlighting the potential psychosocial benefits of effective AA treatment.

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Research cited in this study

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research Long-Term Efficacy and Safety of Baricitinib in Patients With Severe Alopecia Areata: 104-Week Results From BRAVE-AA1 and BRAVE-AA2

February 2024 in “Journal of the European Academy of Dermatology and Venereology”

Baricitinib is effective and safe for long-term use in severe alopecia areata, improving hair regrowth and quality of life with few side effects.

Improvement in Health-Related Quality of Life and Symptoms of Anxiety and Depression in Patients with Alopecia Areata Randomized to Baricitinib or Placebo: Results from Two International Randomized Controlled Trials

research Improvement in Health-Related Quality of Life and Symptoms of Anxiety and Depression in Patients with Alopecia Areata Randomized to Baricitinib or Placebo: Results from Two International Randomized Controlled Trials

November 2023 in “JEADV Clinical Practice”

Patients with severe alopecia areata felt better and less anxious or depressed when treated with baricitinib compared to placebo.

Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials

research Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials

September 2023 in “British Journal of Dermatology”

Hair regrowth from severe alopecia areata treatment with baricitinib can vary, with faster results in those with shorter hair loss duration.

Scalp Hair Regrowth Is Associated With Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata: Results From Two Randomized Controlled Trials

research Scalp Hair Regrowth Is Associated With Improvements in Health-Related Quality of Life and Psychological Symptoms in Patients With Severe Alopecia Areata: Results From Two Randomized Controlled Trials

3 citations , June 2023 in “Journal of dermatological treatment”

Regrowing scalp hair improves quality of life and reduces anxiety and depression in severe alopecia areata patients.

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , January 2023 in “Journal of the European Academy of Dermatology and Venereology”

Alopecia areata greatly affects people's life quality, mental health, and work life.

research The Association of Alopecia Areata-Related Emotional Symptoms with Work Productivity and Daily Activity Among Patients with Alopecia Areata

29 citations , December 2022 in “Dermatology and Therapy”

Emotional symptoms from alopecia areata reduce work productivity and daily activity.

research Economic Burden and Healthcare Resource Use of Alopecia Areata in an Insured Population in the USA

12 citations , April 2022 in “Dermatology and therapy”

Alopecia areata leads to significantly higher healthcare costs due to more doctor visits and prescriptions.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care

20 citations , February 2022 in “British Journal of Dermatology”

People with alopecia areata have a higher risk of depression and anxiety, and often face unemployment and work absences.

research Patient Perspectives of the Social, Emotional and Functional Impact of Alopecia Areata: A Systematic Literature Review

67 citations , March 2021 in “Dermatology and Therapy”

‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

research ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata

30 citations , September 2020 in “Journal of Patient-Reported Outcomes”

Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.

research The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials

86 citations , January 2020 in “British Journal of Dermatology”

The AA-IGA scale reliably measures treatment success in alopecia areata by considering both clinician and patient views.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations , November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations , September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

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research Serum Zinc Concentration in Patients With Alopecia Areata

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