Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

July 2024 in “ Skin Research and Technology ”

W. Du, Ke He, Xin-Yi Liu, Tingyi Yin, Shengxiang Xiao, Yan Zheng

alopecia areata androgenetic alopecia cicatricial alopecia Mendelian randomization AA AGA CA

Studysummary Asthma may increase the risk of alopecia areata.

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The study explored the genetic link between asthma and alopecia using a two-sample Mendelian randomization approach, involving 408,442 European participants for asthma and 211,139 for alopecia areata (AA). It found a causal relationship between asthma and an increased risk of AA, with an odds ratio of 1.859, confirmed by various methods. No causal link was found between asthma and androgenic alopecia (AGA) or cicatricial alopecia (CA). The study suggests shared genetic and immune pathways between asthma and AA, involving Th2 cells and cytokines. Despite robust sensitivity analyses, limitations include a smaller sample size and lack of sex-specific or ethnic-stratified analyses, indicating a need for further research.

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Research cited in this study

18 / 18 results

research Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

3 citations , July 2024 in “Skin Research and Technology”

Asthma may increase the risk of alopecia areata.

research Causal Effects of Genetically Determined Metabolites on Androgenetic Alopecia: A Two-Sample Mendelian Randomization Analysis

May 2024 in “Skin research and technology”

This study used Mendelian randomization analysis to identify Scyllo-inositol and Alpha-ketoglutarate as potential protective factors and Heme and 2-palmitoylglycerophosphocholine as risk factors for androgenic alopecia, suggesting a causal link between these metabolites and the condition.

research Retracted: Causal Role of Immune Cells in Alopecia Areata: A Two-Sample Mendelian Randomization Study

14 citations , January 2024 in “Skin Research and Technology”

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

research Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions

4 citations , November 2023 in “Frontiers in immunology”

In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.

research Approach to the Patient With Hair Loss

1 citations , August 2023 in “Journal of the American Academy of Dermatology”

This continuing medical education article outlines the comprehensive approach needed to diagnose alopecia, emphasizing the importance of a thorough history, scalp and hair examination, and, if necessary, laboratory analysis and biopsy for effective treatment planning.

research Androgenetic Alopecia: An Update

July 2023 in “JAAD International”

This study describes androgenetic alopecia as a common non-scarring hair loss condition primarily influenced by genetic factors and androgen sensitivity, notably impacting psychosocial well-being, especially in females and younger males seeking treatment.

Prevalence of Autoimmune and Inflammatory Diseases and Mental Health Conditions Among an Alopecia Areata Cohort from a US Administrative Claims Database

research Prevalence of Autoimmune and Inflammatory Diseases and Mental Health Conditions Among an Alopecia Areata Cohort from a US Administrative Claims Database

1 citations , June 2023 in “Journal of Dermatology”

This study found that patients with alopecia areata had a higher prevalence of autoimmune, inflammatory, and mental health conditions compared to a matched cohort without alopecia areata.

research Differential Impact of Environmental Factors on Systemic and Localized Autoimmunity

5 citations , May 2023 in “Frontiers in immunology”

This review discusses how environmental factors like lifestyle, nutrition, and vitamin deficiencies may influence autoimmune diseases such as MS, SLE, and AA, highlighting associations with vitamin D levels and dietary interventions, but notes a lack of conclusive evidence for their roles in disease pathogenesis.

research Androgenetic Alopecia: Therapy Update

May 2023 in “Drugs”

This comprehensive review analyzes androgenetic alopecia treatments, discussing the mechanisms, costs, efficacy, and safety of FDA-approved drugs like minoxidil and finasteride, as well as newer non-FDA-approved options that have shown effectiveness across various studies.

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

15 citations , January 2023 in “Antioxidants”

This review discusses oxidative stress in alopecia areata pathogenesis and potential treatment strategies, reporting no new clinical results but suggesting biomarkers for oxidative stress and discussing JAK inhibitors as promising options.

research Scalp Biomarkers During Dupilumab Treatment Support Th2 Pathway Pathogenicity in Alopecia Areata

15 citations , October 2022 in “Allergy”

This study found that dupilumab treatment in alopecia areata significantly suppressed Th2-related markers and increased hair keratin levels, suggesting a potential role of Th2 cytokines in the disease's pathogenesis.

research What's New in Therapy for Male Androgenetic Alopecia?

2 citations , September 2022 in “American Journal of Clinical Dermatology”

research Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata

16 citations , January 2022 in “International journal of molecular sciences”

This review summarizes the influences of lifestyle factors such as smoking, alcohol, and diet on the pathogenesis of alopecia areata but reports no new clinical results.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.

research Alopecia Areata Susceptibility Variant in MHC Region Impacts Expressions of Genes Contributing to Hair Keratinization and Is Involved in Hair Loss

19 citations , July 2020 in “EBioMedicine”

In this study, the researchers identified a variant in the CCHCR1 gene associated with an alopecia areata subtype characterized by impaired keratinization and autoimmune events.

Alopecia Areata: A Multifactorial Autoimmune Condition