Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

    July 2024 in “ Skin Research and Technology ”
    W. Du, Ke He, Xin-Yi Liu, Tingyi Yin, Shengxiang Xiao, Yan Zheng
    TLDR Asthma may increase the risk of alopecia areata.
    The study explored the genetic link between asthma and alopecia using a two-sample Mendelian randomization approach, involving 408,442 European participants for asthma and 211,139 for alopecia areata (AA). It found a causal relationship between asthma and an increased risk of AA, with an odds ratio of 1.859, confirmed by various methods. No causal link was found between asthma and androgenic alopecia (AGA) or cicatricial alopecia (CA). The study suggests shared genetic and immune pathways between asthma and AA, involving Th2 cells and cytokines. Despite robust sensitivity analyses, limitations include a smaller sample size and lack of sex-specific or ethnic-stratified analyses, indicating a need for further research.
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