Alopecia Areata Clinical Trial Enrollment and Retention Outcome Factors Among Underrepresented Ethnic and Racial Groups: A Cross-Sectional Study

    July 2023 in “ Journal of the American Academy of Dermatology ”
    Rachel Elsanadi, Ilhan Esse, Celine Phong, Alyssa Ashbaugh Ortega, Katerina Yale, Natasha Atanaskova Mesinkovska
    TLDR Clinical trials for alopecia areata need better inclusion and retention of patients of color.
    This study examined the enrollment and retention of alopecia areata (AA) clinical trial participants across different ethnic and racial groups at the University of California, Irvine. The study involved 115 subjects, with 45.2% White, 24.3% Hispanic, 16.5% Asian, 12.2% Black, and 1.7% Pacific Islanders. Significant differences were found in enrollment and retention rates among these groups. Asian patients had the highest enrollment (84.2%) and lowest screen failure rates (15.8%), while Black patients had the lowest enrollment (42.9%) and highest screen failure rates (57.1%). Black patients also had higher withdrawal and early termination rates. The study highlights the need for improved diagnosis and evaluation of hair loss conditions among patients of color and suggests that addressing these disparities could lead to more representative clinical trial results.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Binding affinity of pyrilutamide!

      in Update  169 upvotes 3 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community Alopecia Areata Question

      in Treatment  2 upvotes 5 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

    Related Research

    1 / 1 results