The Role of Minoxidil in the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis

    December 2024 in “ Journal of Clinical Medicine
    M. Majewski, Karolina Gardaś, Anna Waśkiel‐Burnat, Michał Ordak, Lidia Rudnicka
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    TLDR Minoxidil shows promise for alopecia areata, but more research is needed before it can be recommended as a primary treatment.
    This systematic review and meta-analysis evaluated the efficacy of minoxidil as a monotherapy for alopecia areata, analyzing 13 studies with 372 patients. It found that 5% topical minoxidil had an 82% response rate, significantly higher than lower concentrations. Oral minoxidil also showed an 82% response rate, but due to a small sample size, it was not included in the meta-analysis. Despite promising results, the study concluded that there is insufficient data to recommend minoxidil as a first-line treatment for alopecia areata. The study highlighted the need for further research due to limitations such as a small number of studies, lack of long-term data, and variability in study design.
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