Direct T-Cell Effects of Minoxidil

The document discussed the effects of minoxidil on T-cells in the context of alopecia areata, a condition characterized by miniaturized hair follicles and dense perifollicular T lymphocyte infiltration. Minoxidil was shown to induce hair regrowth, potentially through immunomodulatory effects. Specifically, treatment with 5% topical minoxidil resulted in a decrease in tissue T cells and an increase in peripheral blood T cells among responders, suggesting a shift in T-cell populations. This indicated that T lymphocytes might play a significant role in the pathogenesis of hair loss in alopecia areata, and minoxidil's efficacy could be linked to its impact on these immune cells.