Response to Minoxidil in Severe Alopecia Areata Correlates With T Lymphocyte Stimulation

December 1987 in “ British Journal of Dermatology ”

Virginia C. Fiedler‐Weiss, Cunera Buys

minoxidil alopecia areata T lymphocyte T cell blastogenesis topical treatment Rogaine

From the encyclopedia

An essential vasodilator with some anti-androgenic effects

autoimmune disorder causing patchy hair loss

Studysummary This study suggests that increased T cell blastogenesis may predict a positive response to topical 5% minoxidil treatment in patients with severe alopecia areata.

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In a study involving 47 patients with severe alopecia areata, researchers found that 36 responders who experienced terminal hair regrowth after treatment with topical 5% minoxidil showed significantly increased T cell blastogenesis before treatment, which decreased to control levels following hair regrowth. In contrast, non-responders exhibited no significant differences in lymphocyte stimulation compared to controls, both before and after treatment. These findings suggested that enhanced T cell blastogenesis could predict the response to minoxidil therapy in severe alopecia areata cases.

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Research cited in this study

11 / 11 results

research Potential Mechanisms of Minoxidil-Induced Hair Growth in Alopecia Areata

26 citations , March 1987 in “Journal of the American Academy of Dermatology”

This study suggests that topical minoxidil may aid hair regrowth in alopecia areata through synergistic effects on follicular epithelium and lymphocyte-mediated immunological responses, alongside its vasodilatory properties.

research Topical Minoxidil Solution (1% and 5%) in the Treatment of Alopecia Areata

101 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

11 citations , February 1986 in “Archives of Dermatology”

This study found that 5% topical minoxidil solution led to better hair regrowth response and quality in severe alopecia areata compared to 1% solution, despite regrowth often being cosmetically unacceptable.

research Topical Minoxidil Dose-Response Effect in Alopecia Areata

54 citations , February 1986 in “Archives of Dermatology”

This study found that 5% topical minoxidil solution led to greater hair regrowth in severe alopecia areata patients compared to 1% minoxidil, although most regrowth was not cosmetically acceptable.

research In Vitro Suppression of Human Lymphocyte Activity by Minoxidil

17 citations , January 1985 in “International Journal of Dermatology”

In this study, minoxidil was found to suppress the activity of normal human T-lymphocytes in vitro, though the physiological relevance of this effect remains uncertain.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

research Alopecia Areata Treated With Topical Minoxidil

78 citations , April 1984 in “Archives of Dermatology”

This study found that 1% minoxidil topical solution led to terminal hair regrowth in some patients with alopecia areata, though it was only cosmetically acceptable in less than half of those cases.

research Alopecia Areata Treated With Topical Minoxidil

16 citations , April 1984 in “Archives of Dermatology”

This study found that 1% minoxidil topical solution led to terminal hair regrowth in 25 out of 48 patients with alopecia areata, but only 11 patients achieved cosmetically acceptable results.

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations , January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations , October 1983 in “BMJ”

This study found that 1% topical minoxidil induced significant hair regrowth in patients with alopecia areata, though it was less effective for those with extensive hair loss such as alopecia totalis and universalis.