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GlossaryCAG Repeats

repeated DNA sequences of cytosine, adenine, and guanine

CAG repeats refer to sequences of three DNA nucleotides—cytosine, adenine, and guanine—that are repeated multiple times in a row within a gene. These repeats can expand abnormally in certain genetic disorders, such as Huntington's disease, leading to the production of malfunctioning proteins and subsequent cellular damage.

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research No Evidence That 2D:4D Is Related to the Number of CAG Repeats in the Androgen Receptor Gene

40 citations, January 2013 in “Frontiers in Endocrinology”

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

research Shorter CAG Repeats in the Androgen Receptor Gene May Enhance Hyperandrogenicity in Polycystic Ovary Syndrome

37 citations, January 2008 in “Gynecological Endocrinology”

Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.

research Polymorphism of CAG and GGN Repeats of Androgen Receptor Gene in Women with Polycystic Ovary Syndrome

9 citations, September 2015 in “Reproductive Biomedicine Online”

Longer GGN repeats in the androgen receptor gene are linked to polycystic ovary syndrome.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

research Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss Patients

10 citations, November 2010 in “Journal of Dermatology”

Longer CAG repeats in gene linked to more severe hair loss in females.

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community 3 months 5g Min only before/after, 26 y/o

in Is this regrowth? 451 upvotes 1 month ago

The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 4 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community Found this meme on a forum……..

in Satire 150 upvotes 1 year ago

The conversation is about a meme related to hair loss that influenced someone to start taking finasteride. Another person agrees that the meme accurately represents the situation.

community Long term minoxidil as a permanent solution

in Minoxidil 27 upvotes 3 years ago

A user is considering using minoxidil for hair loss and asks for advice on application and long-term effectiveness. Responses suggest minoxidil can be effective but may lose efficiency over time, and combining it with other treatments like finasteride might be more beneficial.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 451 upvotes 5 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

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