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GlossaryCAG Repeats (CAG Trinucleotide Repeat)

repeated DNA sequences of cytosine, adenine, and guanine

CAG repeats refer to sequences of three DNA nucleotides—cytosine, adenine, and guanine—that are repeated multiple times in a row within a gene. These repeats can expand abnormally in certain genetic disorders, such as Huntington's disease, leading to the production of malfunctioning proteins and subsequent cellular damage.

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Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

research Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

14 citations, December 2016 in “Sexual Medicine”

Finasteride side effects in young men may be linked to specific gene variations.

research CAG Polymorphism in the Androgen Receptor Gene in Women May Be Associated with Nodulocystic Acne

7 citations, January 2019 in “Postepy Dermatologii I Alergologii”

Certain gene variations might be linked to severe acne in women but not in men.

research Shorter CAG Repeats in the Androgen Receptor Gene May Enhance Hyperandrogenicity in Polycystic Ovary Syndrome

37 citations, January 2008 in “Gynecological Endocrinology”

Shorter CAG repeats in a specific gene may increase male hormone activity and symptoms like acne and excess hair in women with PCOS.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation

research A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation

16 citations, December 2014 in “International Journal of Biological Markers”

Longer CAG and GGN repeats increase alopecia risk, but no significant link to post-finasteride syndrome found.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 443 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.