Role of Polymorphism of the Androgen Receptor Gene and Non-Random X Chromosome Inactivation in the Genesis of Androgenic Alopecia in Women of Childbearing Potential

    April 2011 in “ Vestnik dermatologii i venerologii ”
    A. N. Mareyeva, I. A. Volkov, Rotanov Sv, N. V. Frigo, Galina E. Chernukha
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    TLDR Certain gene variations and irregular X chromosome activity may contribute to hair loss in women who can have children.
    The study conducted by MAREYEVA AN1, VOLKOV IA1, ROTANOV SV1, FRIGO NV1, CHERNUKHA GY.1 in 2011 investigated the role of polymorphism of the androgen receptor gene and non-random X chromosome inactivation in the development of androgenic alopecia in 87 women of childbearing potential. The researchers found a significant association between the presence of 'short' (≤ 22) CAG repeats in both alleles of the androgen receptor gene and a higher prevalence of non-random X chromosome inactivation in patients with androgenic alopecia compared to healthy women (50.7% (39/77) and 16.1% (9/56), respectively, р < 0.05). These findings suggest that polymorphism of the androgen receptor gene and non-random X chromosome inactivation play a pathogenic role in the development of androgenic alopecia in women of childbearing potential.
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