Role of Polymorphism of the Androgen Receptor Gene and Non-Random X Chromosome Inactivation in the Pathogenesis of Androgenic Alopecia

    December 2010 in “ Vestnik dermatologii i venerologii ”
    A. N. Mareeva
    Studysummary This article reviews molecular and genetic mechanisms in the development of androgenic alopecia and examines the relationship between androgen receptor gene polymorphism and androgen-dependent diseases, but reports no new clinical results.
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    Research cited in this study 21

    1. Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia International Journal of Dermatology · 2009
    2. Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss British Journal of Dermatology · 2009
    3. Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26 American Journal of Human Genetics · 2008
    4. Androgen Receptor Gene CAG Repeat Polymorphism in Women with Polycystic Ovary Syndrome Fertility and Sterility · 2008
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    6. Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia British Journal of Dermatology · 2007
    7. Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism Journal of Investigative Dermatology Symposium Proceedings · 2005
    8. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    9. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005
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    13. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    14. Molecular Genetic and Endocrine Mechanisms of Hair Growth Hormone Research in Paediatrics · 2003
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    16. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
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    20. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    21. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993