Role of Polymorphism of the Androgen Receptor Gene and Non-Random X Chromosome Inactivation in the Pathogenesis of Androgenic Alopecia

    December 2010 in “ Vestnik dermatologii i venerologii ”
    A. N. Mareeva
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    TLDR Certain genes and X chromosome patterns may significantly contribute to the development of hair loss.
    The study conducted 12 years ago explored the connection between the polymorphism of the androgen receptor gene and non-random X chromosome inactivation in the onset of androgenic alopecia. The researchers discovered a link between the polymorphism of the androgen receptor gene, particularly the CAG repeat length in exon 1, and androgen-dependent diseases such as alopecia. This indicates that genetic factors and X chromosome inactivation patterns could have a substantial role in the development of androgenic alopecia.
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