Androgen Receptor Gene CAG Repeat Polymorphism in Women with Polycystic Ovary Syndrome

    January 2008 in “ Fertility and Sterility ”
    Jin Ju Kim, Seon Ha Choung, Young Min Choi, Sang Ho Yoon, Seok Hyun Kim, Shin Yong Moon
    Image
    Studysummary This study suggests that androgen receptor gene CAG repeat length may influence serum free testosterone levels in some PCOS patients, with longer repeats associated with higher testosterone concentrations.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study, which included 114 women with polycystic ovary syndrome (PCOS) and 205 controls, explored the connection between the length of CAG repeats in the androgen receptor (AR) gene and serum androgen levels in women with PCOS. It found no significant difference in CAG repeat length between the PCOS group and the control group. However, among the PCOS patients, those with higher free testosterone levels had significantly longer CAG repeat lengths. There was also a significant correlation between the average CAG repeat length and free testosterone concentration in the PCOS group. The findings suggest that while AR gene CAG repeat polymorphism does not directly cause PCOS, it may influence serum free testosterone concentrations in women with the condition, with longer repeats being associated with higher androgen levels.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results