Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

April 1999 in “ Dermatologic Clinics ”

Keith D. Kaufman

androgen metabolism hair growth androgenetic alopecia androgens DHT 5α-reductase inhibitors finasteride enzyme activity hair follicles sebaceous glands Propecia

TLDR Androgens, like DHT, affect hair growth and treatments like finasteride may help.

This 1999 document explores the relationship between androgen metabolism and hair growth in androgenetic alopecia. It suggests that androgens, particularly DHT, play a role in the development of the condition. The document discusses the use of 5α-reductase inhibitors, such as finasteride, as a potential treatment option for reducing DHT levels and promoting hair growth. The study also found differences in enzyme activity in hair follicles and sebaceous glands in individuals with androgenetic alopecia.

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

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