Clinical Use of 5α-Reductase Inhibitors

    January 2001 in “ Cambridge University Press eBooks ”
    Keith D. Kaufman
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    TLDR Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
    The document reviewed the clinical use of 5α-reductase inhibitors, particularly finasteride, for treating androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH). Finasteride was shown to significantly reduce dihydrotestosterone (DHT) levels, leading to increased hair growth in men with AGA and reduced prostate volume in men with BPH. Long-term studies confirmed its efficacy and safety, with mild and transient side effects, primarily related to sexual function. Finasteride was ineffective in treating acne and postmenopausal women with AGA. The document also discussed the potential of finasteride in reducing prostate cancer incidence, though with a slight increase in high-grade cancers. Dutasteride, another 5α-reductase inhibitor, was approved for BPH but not AGA.
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      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

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      in Research/Science  67 upvotes 11 months ago
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      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 9 months ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

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