Clinical Use of 5α-Reductase Inhibitors

    January 2001 in “ Cambridge University Press eBooks ”
    Keith D. Kaufman
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    TLDR Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
    The document reviewed the clinical use of 5α-reductase inhibitors, particularly finasteride, for treating androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH). Finasteride was shown to significantly reduce dihydrotestosterone (DHT) levels, leading to increased hair growth in men with AGA and reduced prostate volume in men with BPH. Long-term studies confirmed its efficacy and safety, with mild and transient side effects, primarily related to sexual function. Finasteride was ineffective in treating acne and postmenopausal women with AGA. The document also discussed the potential of finasteride in reducing prostate cancer incidence, though with a slight increase in high-grade cancers. Dutasteride, another 5α-reductase inhibitor, was approved for BPH but not AGA.
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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

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      in Research  330 upvotes 3 months ago
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      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 10 months ago
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