In Vitro 5α-Reductase Inhibition by Selected Ayurvedic Herbs for Androgenic Disorders

    Anirban Kr Chakrabarty, Dipankar Banerjee, Rajiva Kumar … Sunil Kumar Dubey
    Studysummary This study evaluated the 5α-reductase inhibitory effects of several Ayurvedic herbs and found that Eclipta alba exhibited the highest activity, suggesting its potential for use in treatments for androgenic disorders like alopecia.
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    Research cited in this study 14

    1. Phytochemicals With Anti 5-Alpha-Reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021
    2. Phytochemistry, Pharmacological Activity, And Potential Health Benefits Of Glycyrrhiza Glabra Heliyon · 2021
    3. Hormonal Therapy in Female Pattern Hair Loss International Journal of Women's Dermatology · 2017
    4. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health Evidence-based Complementary and Alternative Medicine · 2017
    5. Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review PubMed · 2016
    6. Evaluation of 5α-Reductase Inhibitory Activity of Certain Herbs Useful as Antiandrogens Andrologia · 2013
    7. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    8. 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment Journal of Ethnopharmacology · 2011
    9. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    10. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    11. Male Androgenetic Alopecia The Journal of Men's Health & Gender · 2004
    12. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    13. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    14. Novel Agents for the Treatment of Alopecia Seminars in Cutaneous Medicine and Surgery · 1998