In Vitro 5α-Reductase Inhibition by Selected Ayurvedic Herbs for Androgenic Disorders

    October 2024 in “ International Journal of Ayurveda Research ”
    Anirban Kr Chakrabarty, Dipankar Banerjee, Rajiva Kumar, Chandra Kant Katiyar, Sunil Kumar Dubey
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    TLDR Emblica officinalis and Eclipta alba may help treat hair loss naturally.
    This study examines the inhibitory effects of six Ayurvedic herbs on the enzyme 5α-reductase, which is linked to androgenic disorders such as androgenic alopecia. The herbs tested include Prunus dulcis, Aloe barbadensis, Bacopa monnieri, Glycyrrhiza glabra, Emblica officinalis, and Eclipta alba. Results indicate that all extracts showed promising inhibitory activity, with Emblica officinalis and Eclipta alba having the most significant effects. The study suggests these herbs could be natural alternatives to synthetic inhibitors like finasteride and dutasteride, which have side effects. The research also notes that most herbal aqueous extracts have similar effects to water extracts, except for Aloe barbadensis, which is more potent in its water extract form. These findings support the potential use of these herbs in therapeutic applications for managing alopecia and in haircare products.
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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

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      by nkrata in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

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