TLDR New compounds with carborane showed anti-androgen effects similar to flutamide.
The study reported the design and synthesis of novel androgen receptor antagonists incorporating carborane moieties, which are known for their chemical and thermal stability and hydrophobic character. Compounds 8a, 8c, and 9d demonstrated anti-androgenic activity comparable to flutamide in assays using NIH3T3 cells transfected with a human AR expression plasmid. The findings suggested that the carborane cage served as an effective hydrophobic pharmacophore for androgen receptor antagonism.
72 citations
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June 1979 in “Biochemical Society Transactions” Flutamide and its metabolite can effectively reduce androgen effects.
88 citations
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February 2008 in “Journal of Medicinal Chemistry” Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.
16 citations
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August 2021 in “Tumor Biology” TMPRSS2 helps viruses enter cells and protects the prostate from inflammation-related cancer.
The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.
5 citations
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June 2022 in “Frontiers in Endocrinology” Research from 2011 to 2020 shows androgen receptors could be key for prognosis and treatment in certain breast cancers.
11 citations
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March 2009 in “Bioorganic & Medicinal Chemistry Letters” Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.
