Expression of Sex-Determining Genes in the Scalp of Men with Androgenetic Alopecia

    March 2007 in “ Dermatology
    WenChieh Chen, Chao Yang, Ren-Yeu Tsai, Chen-Yu Liao, Yu-Ta Yen, Chiu-Ling Hung, Ko-Fan Chen, Shaw Jenq Tsai, Christos C. Zouboulis
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    TLDR Sex-determining genes may affect male baldness.
    This study examined the expression of sex-determining genes in the scalp of men with androgenetic alopecia (AGA). The researchers found that the expression of certain genes, including SRY and WT-1, was significantly higher in the bald areas of men with AGA. The study suggests that sex-determining genes may play a role in the pathogenesis of AGA, but further research on a larger population is needed to confirm this.
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