Differential Expression of Retinoic Acid-Synthesizing (RALDH) Enzymes During Fetal Development and Organ Differentiation in the Mouse

    January 2002 in “ Mechanisms of development
    Karen Niederreither, Valérie Fraulob, Jean‐Marie Garnier, Pierre Chambon, Pascal Dollé
    TLDR Different enzymes are active in different parts of developing mouse organs.
    The study examined the expression of retinoic acid-synthesizing enzymes Raldh1, Raldh2, and Raldh3 during mouse fetal development and organ differentiation. Raldh1 was prominently expressed in the lung, stomach, intestine, and specific brain structures postnatally, while Raldh2 was found in the kidney nephrogenic zone and mesenchyme of various organs. Raldh3 was specific to the intestinal lamina propria and certain epithelial tissues. Additionally, Raldh1 was highly expressed in ventral mesencephalic cells, including the substantia nigra, until adulthood, and Raldh3 was found in the lateral ventricle septal fork and the superficial layer of the posterior cerebral cortex at postnatal stages. In developing hair follicles, Raldh3 was expressed at the base of the follicles at 5 days post-partum, with Raldh1 coexpressed at weaker levels, but these patterns were not observed at 3 weeks post-partum. The distinct expression patterns indicated a regulated requirement for retinoic acid synthesis in various differentiating organs, highlighting their roles in organogenesis and tissue differentiation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 126 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Minoxidil works only with Retinoic acid

      in Minoxidil  301 upvotes 4 days ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

      community How important are Retinoic and Hydrocortisone in topical serum?

      in Treatment  4 upvotes 7 months ago
      The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

    Similar Research

    5 / 1000+ results