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    Glossary Keratinocyte

    cell producing keratin, forming most of the skin's outer layer

    A keratinocyte is a type of cell that makes up the majority of the outer layer of the skin, known as the epidermis. These cells produce keratin, a protein that helps protect the skin from damage, infection, and water loss. For professionals, it's important to note that keratinocytes originate in the basal layer of the epidermis and move upwards, undergoing a process of differentiation and eventually forming the stratum corneum, the outermost layer of dead cells.

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    1. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003 · 561 citations
    2. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    3. Location and phenotype of human adult keratinocyte stem cells of the skin Differentiation · 2004 · 233 citations
    4. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    5. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    6. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    7. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020 · 147 citations
    8. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    9. Vitamin D receptor is essential for normal keratinocyte stem cell function Proceedings of the National Academy of Sciences · 2007 · 143 citations
    10. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993 · 133 citations
    11. Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation Experimental Cell Research · 1989 · 128 citations
    12. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    13. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    14. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001 · 115 citations
    15. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice* Endocrinology · 2000 · 114 citations
    16. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    17. Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair 2000 · 113 citations
    18. Expression of μ-Opiate Receptor in Human Epidermis and Keratinocytes Journal of Investigative Dermatology · 1998 · 111 citations
    19. Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation. The Journal of Cell Biology · 1994 · 104 citations
    20. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    21. Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development PLoS ONE · 2010 · 101 citations
    22. Pemphigus Vulgaris IgG and Methylprednisolone Exhibit Reciprocal Effects on Keratinocytes Journal of Biological Chemistry · 2004 · 99 citations
    23. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    24. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations
    25. Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial–Mesenchymal Interactions 1999 · 92 citations
    26. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    27. miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes Journal of Investigative Dermatology · 2020 · 90 citations
    28. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    29. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice EMBO molecular medicine · 2014 · 81 citations
    30. Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes ˜The œAmerican journal of pathology · 2005 · 81 citations