Role Of Extracellular Vesicles As Mediators Of Cell Communication And Novel Biomarkers In Sepsis

Small extracellular vesicles (sEVs) are emerging as crucial mediators of cell communication and potential biomarkers in sepsis, a severe condition caused by an uncontrolled immune response to infection. This review highlights the role of sEVs in sepsis, emphasizing their ability to transfer bioactive molecules and reflect the physiological state of their origin cells. sEVs offer real-time insights into immune activation and inflammation, making them promising candidates for liquid biopsy, a minimally invasive diagnostic approach. The review discusses the mechanisms of sEVs in immune modulation, their biogenesis, uptake, and their potential in improving early detection, guiding treatment, and advancing personalized medicine in sepsis management.