26 citations
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July 2021 in “Frontiers in Cell and Developmental Biology” This review discusses mesenchymal stromal cell-conditioned medium for various skin conditions and found improvements in wound healing, hair restoration, and more, but emphasizes the need for further research to validate these findings.
2 citations
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January 2013 in “Hair therapy & transplantation” This review discusses surgical and future therapeutic options for cicatricial alopecia and reports no clinical results; the authors emphasize the need for more options for patients without active disease signs.
7 citations
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January 2012 in “PubMed” In this study, azelaic acid 20% and finasteride increased BCL-2 protein expression and decreased bax protein expression in rats after skin flap surgery, suggesting a potential antiapoptotic role in reducing ischemia-induced damage.
116 citations
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April 2022 in “Science Translational Medicine” This study found that the hydrophilic PTK-UR foam with EG7 repeats significantly improved wound healing in porcine skin wounds compared to other scaffolds, suggesting potential for synthetic biomaterial applications.
This review examines the physiology of skin flap necrosis and various substances studied to improve flap viability, noting that promising results are mostly from animal studies, with nitroglycerin already tested in humans.