Current Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseases

The document reviewed advanced therapies using human mesenchymal stem cells (hMSCs) for treating various skin diseases, focusing on research from 2015 to 2020. hMSCs, known for their regenerative and immunomodulatory properties, were explored for their potential in conditions like wound healing, psoriasis, atopic dermatitis, and burn injuries. Preclinical and clinical studies demonstrated promising results, with hMSCs enhancing wound closure, reducing inflammation, and improving skin quality. Notably, 16 clinical trials favored allogeneic hMSCs, particularly from adipose tissue, showing significant benefits in wound healing. However, challenges such as optimizing delivery methods and standardizing treatment protocols were noted, indicating the need for further research to fully understand the efficacy and safety of hMSC-based therapies in clinical applications.