Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges

The document reviewed the use of skin-derived stem cells for wound treatment, particularly focusing on cultured epidermal autografts (CEAs). CEAs showed promise in improving wound healing and reducing scar formation, with applications in treating burns, chronic wounds, and genetic skin disorders. They offered advantages over conventional skin grafts by avoiding secondary wounds and reducing scars. However, challenges such as long production times, high costs, variable engraftment rates, and complications like infections and graft failure limited their widespread application. Despite successful clinical trials, issues like high manufacturing costs and limited regeneration of skin appendices persisted, necessitating further research to optimize these regenerative approaches and improve therapeutic outcomes.