Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells

The study explores the role of platelet-derived mitochondria in enhancing wound healing by reducing oxidative stress and apoptosis in endothelial cells, specifically human umbilical vein endothelial cells (HUVECs). The research demonstrates that mitochondria from platelets can be transferred to these cells, improving cell viability, decreasing reactive oxygen species (ROS) levels, and reducing apoptosis, particularly under oxidative stress conditions induced by hydrogen peroxide (H2O2). The study highlights the effectiveness of ultrasound in activating platelets to release mitochondria, which enhance ATP production and protect cells from oxidative damage. Key findings include the upregulation of the survivin gene, which is crucial for cell division and inhibiting apoptosis, suggesting that platelet-derived mitochondria could be a promising therapeutic strategy for oxidative damage and wound healing. The study's results are supported by statistical analyses confirming their significance (p < 0.05).