Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair

The document reviews advancements in Pluronic F127 derivatives for wound healing, emphasizing their potential in creating effective wound dressings. Pluronic F127 is a thermoresponsive, biocompatible hydrogel that forms a porous structure at body temperature, suitable for wound treatment. Derivatives like aldehyde-terminated F127 enhance mechanical strength, self-healing, and tissue adhesion, and can load therapeutic substances to promote healing. Studies show these hydrogels, combined with agents like silver nanoparticles, exhibit strong antibacterial properties and promote tissue regeneration, making them promising alternatives to conventional treatments for various wounds, including burns and diabetic wounds. Future research aims to enhance these properties through chemical and physical modifications and by integrating nanomaterials.