Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair

August 2023 in “ International Journal of Nanomedicine ”

Shanshan Li, Cheng Yang, Junqiang Li, Chao Zhang, Liaoliao Zhu, Yang Song, Yongdong Guo, Ronglin Wang, Dongxue Gan, Jingjie Shi, Peixiang Ma, Fei Gao, Haichuan Su

Pluronic F127 hydrogel aldehyde-terminated F127 silver nanoparticles wound healing tissue regeneration nanomaterials

Studysummary This review discusses the potential of Pluronic F127-derived hydrogels for wound healing, examining their applications in various wound types and exploring underlying mechanisms and their interaction within the wound microenvironment. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviews advancements in Pluronic F127 derivatives for wound healing, emphasizing their potential in creating effective wound dressings. Pluronic F127 is a thermoresponsive, biocompatible hydrogel that forms a porous structure at body temperature, suitable for wound treatment. Derivatives like aldehyde-terminated F127 enhance mechanical strength, self-healing, and tissue adhesion, and can load therapeutic substances to promote healing. Studies show these hydrogels, combined with agents like silver nanoparticles, exhibit strong antibacterial properties and promote tissue regeneration, making them promising alternatives to conventional treatments for various wounds, including burns and diabetic wounds. Future research aims to enhance these properties through chemical and physical modifications and by integrating nanomaterials.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells

27 citations , February 2023 in “Oxidative Medicine and Cellular Longevity”

This study found that platelet-derived mitochondria can promote wound healing by reducing oxidative stress-induced apoptosis in vascular endothelial cells, with survivin identified as a potential target.

research Injectable Self-Healing Ceria-Based Nanocomposite Hydrogel with ROS-Scavenging Activity for Skin Wound Repair

26 citations , December 2021 in “Regenerative Biomaterials”

This study found that an injectable ceria-based nanocomposite hydrogel improved wound healing and epithelium regeneration, including hair follicle and adipocyte tissue formation, in full-thickness skin wound models.

Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

research Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

61 citations , September 2020 in “Bioactive Materials”

This study found that the multifunctional FEA-PCEI dressing significantly accelerated wound healing, reduced scar formation, and promoted hair follicle neogenesis while providing antibacterial and anti-inflammatory benefits.

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

518 citations , November 2014 in “Science”

This review discusses current and experimental treatments for cutaneous wounds, emphasizing cell-based therapies and skin transplantation, but reports no new clinical results.