Particulate 3D Hydrogels of Silk Fibroin-Pluronic to Deliver Curcumin for Infection-Free Wound Healing
August 2024
in “
Biomimetics
”
New to Curcumin? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, researchers developed a silk fibroin-based hydrogel with added curcumin and pluronic F127, which displayed antibacterial properties against Methicillin-resistant Staphylococcus aureus and showed potential for skin tissue regeneration, without cytotoxicity.
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The study developed silk fibroin-pluronic F127 hydrogels incorporating curcumin for enhanced wound healing, demonstrating significant antibacterial properties and biocompatibility. The hydrogels mimic the skin's hierarchical structure and effectively reduce bacterial growth, achieving over 99% reduction in both planktonic and adherent bacteria, including methicillin-resistant Staphylococcus aureus. Curcumin enhances the hydrogels' structural stability and antibacterial efficiency, while cytotoxicity tests confirm their non-toxicity. The hydrogels show a suitable degradation rate for tissue regeneration, making them promising candidates for infection-free wound dressing applications.
