Vital Roles of Stem Cells and Biomaterials in Skin Tissue Engineering

January 2015 in “ World Journal of Stem Cells ”

Abu Bakar Mohd Hilmi

stem cells biomaterials skin tissue engineering engineered bilayered skin substitutes scaffold-free techniques skin replacement products cell proliferation cell differentiation grafting

Studysummary This review discusses advances in skin tissue engineering, focusing on scaffold-free approaches and the application of stem cells, and reports no new research findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the advancements in skin tissue engineering, highlighting the shift from traditional scaffold-based methods to scaffold-free techniques. Stem cells played a crucial role in transforming the field by contributing to the development of engineered bilayered skin substitutes. The use of biomaterials and skin replacement products was emphasized as a strategy to enhance cell proliferation, differentiation, and safety during grafting. These innovations aimed to improve the effectiveness and application of skin substitutes in clinical settings.

View this study on wjgnet.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

research Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

99 citations , January 2014 in “Nature communications”

In this study, researchers developed a method to differentiate human iPSCs into cells that can generate all lineages of hair follicles, potentially aiding treatments for hair loss and skin disorders.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations , January 2014 in “Nature Cell Biology”

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

28 citations , September 2013 in “Journal of Investigative Dermatology”

This research reviews the roles of dermal papilla signaling in hair follicle development and suggests new genetic tools could advance bioengineering therapies for alopecia, but it reports no new results.

research Hopx Expression Defines a Subset of Multipotent Hair Follicle Stem Cells and a Progenitor Population Primed to Give Rise to K6+ Niche Cells

74 citations , March 2013 in “Development”

This study found that Hopx labels a long-lived progenitor population in hair follicles, which contributes to hair follicle stem cell homeostasis and has an alternative origin from previously thought progenitors.

Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

research Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

57 citations , January 2013 in “International Journal of Medical Sciences”

This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.

research Development and Homeostasis of the Sebaceous Gland

107 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis

52 citations , February 2012 in “PloS one”

This study found that the absence of Ctip2 in epidermal keratinocytes led to impaired wound healing in mice, affecting cell migration, proliferation, and hair follicle stem cell maintenance.

research A Family Business: Stem Cell Progeny Join the Niche to Regulate Homeostasis

254 citations , January 2012 in “Nature Reviews Molecular Cell Biology”

This review discusses the role of stem cell progeny as integral components of stem cell niches, offering feedback that may influence different stem cell systems' microenvironments, but it presents no new research findings.

research Comparison of Hair Dermal Cells and Skin Fibroblasts in a Collagen Sponge for Use in Wound Repair

5 citations , August 2011 in “Biotechnology and Bioprocess Engineering”

research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations , April 2011 in “Pigment Cell & Melanoma Research”

This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations , December 2009 in “Cell stem cell”

This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.

research Human Hair Follicle Pluripotent Stem Cells Promote Regeneration of Peripheral Nerve Injury: An Advantageous Alternative to ES and iPS Cells

121 citations , June 2009 in “Journal of Cellular Biochemistry”

In this study, human hair follicle pluripotent stem cells transplanted into severed mouse sciatic nerves differentiated into Schwann cells and supported nerve regeneration, offering a promising alternative to embryonic or iPS cells for regenerative medicine.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.

research Hair Follicles and Their Role in Skin Health

16 citations , December 2006 in “Expert Review of Dermatology”

This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”