The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst

This document explores the dual role of cellular senescence, traditionally seen as detrimental, in tissue biology and its unexpected regenerative potential, particularly in hair growth. It highlights how senescent melanocytes can stimulate hair follicle stem cells (HFSCs) and promote hair growth through the osteopontin (OPN)–CD44 signaling pathway, challenging conventional views. Using genetically engineered mouse models, researchers found that senescent melanocytes in nevi secrete factors that activate HFSCs, leading to excessive hair growth. The study identifies OPN as a key mediator, suggesting that senescent cells can act as regenerative catalysts. This research offers new possibilities for treating hair loss and developing precise regenerative medicine strategies by targeting these cellular pathways.