Serum Level of Osteopontin in Patients with Alopecia Areata and Its Correlation with Ocular Changes

January 2021 in “ The Scientific Journal of Al-Azhar Medical Faculty Girls ”

Mai Mohamed A.A. El Gareh, Ghada Abd El-Badea Abd El-Aziz Omar, Sawsan Shalaby, Amal A. Morsy, Radwa O.M. Kamel

alopecia areata osteopontin serum level ocular changes eye manifestations break-up time lens abnormalities fundus abnormalities AA OPN

TLDR Alopecia areata patients have higher osteopontin levels and more eye changes, but their vision remains unaffected.

This study investigated the serum level of osteopontin (OPN) in 40 patients with alopecia areata (AA) and its correlation with ocular changes, compared to 40 healthy controls. Results showed a significant increase in serum OPN levels in AA patients, with a positive correlation between OPN levels and disease duration. No correlation was found between OPN levels and age or severity of alopecia. Patients exhibited more significant eye manifestations, including higher mean break-up time, lens abnormalities, and fundus abnormalities, compared to controls. Despite these findings, visual acuity was not affected in AA patients.

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Research cited in this study

2 / 2 results

research Osteopontin: A New Facilitating Factor in Alopecia Areata Pathogenesis?

7 citations , January 2015 in “PubMed”

Osteopontin may play a role in alopecia areata, but its levels don't predict treatment success.

research Gene Expression of Osteopontin in Alopecia Areata: A Case-Controlled Study

1 citations , October 2014 in “Skin Pharmacology and Physiology”

People with alopecia areata have higher levels of osteopontin, which might be important in the disease's development, but this doesn't relate to how severe the disease is.

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Serum Level of Osteopontin in Patients with Alopecia Areata and Its Correlation with Ocular Changes

Research cited in this study

research Osteopontin: A New Facilitating Factor in Alopecia Areata Pathogenesis?

research Gene Expression of Osteopontin in Alopecia Areata: A Case-Controlled Study

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