Gene Expression of Osteopontin in Alopecia Areata: A Case-Controlled Study

October 2014 in “ Skin Pharmacology and Physiology ”

Amr A. Rateb, Faisal Mohammed, Khadiga S Sayed, Rehab A. Hegazy, Razan R. Al Agha, Laila Ahmed Rashed, Safaa Sayed

osteopontin alopecia areata real-time PCR immunohistochemistry OPN mRNA Severity of Alopecia Tool score OPN AA PCR

From the encyclopedia

Osteopontin →

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary This study found that osteopontin expression was significantly higher in alopecia areata lesions compared to healthy controls, suggesting it may play a role in the disease's pathogenesis.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

6 / 6 results

research Investigative Guidelines for Alopecia Areata

66 citations , May 2011 in “Dermatologic therapy”

This report discusses guidelines for designing alopecia clinical trials that account for variables affecting results, but it presents no new efficacy findings.

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

109 citations , May 2011 in “Dermatologic Therapy”

This article reviews the characteristics, associations, and diagnostic criteria for alopecia areata and reports no new clinical findings; the authors note the disease's unpredictable course and variable prognosis.

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

Gene Expression of Osteopontin in Alopecia Areata: A Case-Controlled Study

Research cited in this study

research Investigative Guidelines for Alopecia Areata

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

research Alopecia Areata Update

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

research Osteopontin Gene Is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner

research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen