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    Glossary Epithelial Differentiation

    process where cells become specialized to form body linings

    Epithelial differentiation is the process by which unspecialized cells develop into specialized epithelial cells that form the lining of surfaces and cavities in the body, such as the skin, hair follicles, and internal organs. This process is crucial for creating barriers and structures that protect the body and facilitate functions like absorption, secretion, and sensation.

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    1. Wnt signaling induces epithelial differentiation during cutaneous wound healing BMC Cell Biology · 2006 · 159 citations
    2. TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition Cold Spring Harbor Perspectives in Biology · 2017 · 82 citations
    3. Epithelial differentiation of human adipose-derived stem cells (hASCs) undergoing three-dimensional (3D) cultivation with collagen sponge scaffold (CSS) via an indirect co-culture strategy Stem Cell Research & Therapy · 2020 · 48 citations
    4. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells Biochemical and Biophysical Research Communications · 2006 · 28 citations
    5. Suprabasal change and subsequent formation of disulfide-stabilized homo- and hetero-dimers of keratins during esophageal epithelial differentiation Journal of Cell Science · 1993 · 28 citations
    6. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    7. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    8. Defining the complex epithelia that comprise the canine claw with molecular markers of differentiation Veterinary Dermatology · 2009 · 6 citations
    9. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    10. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium Mechanisms of Development · 2004 · 56 citations
    11. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin Physiological Genomics · 2004 · 90 citations
    12. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    13. Wnt signaling induces epithelial differentiation during cutaneous wound healing Organogenesis · 2015 · 66 citations
    14. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation Differentiation · 1992 · 28 citations
    15. In vitro Growth and Differentiation of Epithelial Cells derived from Post-embryonic Hair Follicles Australian Journal of Biological Sciences · 1982 · 7 citations
    16. Wnt-10b promotes differentiation of skin epithelial cells in vitro Biochemical and Biophysical Research Communications · 2006 · 36 citations
    17. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    18. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    19. UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia Proceedings of the National Academy of Sciences · 2025
    20. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    21. Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles Research Square (Research Square) · 2022
    22. Local Microenvironment Provides Important Cues for Cell Differentiation in Lingual Epithelia PloS one · 2012 · 6 citations
    23. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    24. Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999 · 69 citations
    25. Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer Cells · 2020 · 22 citations
    26. Multifaceted role of keratins in epithelial cell differentiation and transformation Journal of Biosciences · 2019 · 50 citations
    27. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle Genes & development · 2001 · 165 citations
    28. CLED: A Calcium-Linked Protein Associated with Early Epithelial Differentiation Experimental Cell Research · 2000 · 33 citations
    29. Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids The Ocular Surface · 2022 · 19 citations
    30. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations