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research Characterization of Soluble Protein Extracts from Keratinized Tissues: identification of Ubiquitin Universally Distributed in Hair, Nail, and Stratum Corneum

10 citations , January 2001 in “Bioscience Biotechnology and Biochemistry”

This study found that partial protein extraction from keratinized tissues, such as hair and nails, reveals protein patterns distinct from whole protein extracts, including the presence of ubiquitin.

research Anti-programmed cell death protein 1-induced lichenoid changes of the nail unit: Histopathologic description

12 citations , March 2021 in “JAAD Case Reports”

This study reported that immunotherapy in cancer patients can lead to skin-related immune adverse events, such as rashes, pruritus, and vitiligo, affecting a substantial proportion of patients.

research Microtubule associated protein (MAP‐2) expression defines the companion layer of the anagen hair follicle and an analogous zone in the nail unit

14 citations , October 2002 in “Journal of cutaneous pathology”

This study found that MAP-2 is intensely expressed in the companion layer of the hair follicle, suggesting its potential importance to follicle integrity and possible involvement in some types of alopecia.

research Trichohyalin: A structural protein of hair, tongue, nail, and epidermis

27 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

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Community Join

5 / 81 results

community Collagen peptides: Yay or nay?

5 upvotes 6 years ago

Collagen peptides may help with hair growth, but results vary; some users noticed less hair fall and improved nail strength. Minoxidil is suggested for regaining hair thickness lost from accutane.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community 21M, Dermatologist prescribed only Minoxidil

7 upvotes 2 years ago

A 21-year-old was diagnosed with early-stage androgenetic alopecia and prescribed only minoxidil 5% and ketoconazole shampoo by a dermatologist, who advised against finasteride for now. The user is skeptical about starting minoxidil due to concerns about increased hair loss.

community is there anything that stops hair loss?

8 upvotes 1 year ago

A user is experiencing rapid hair loss and has been diagnosed with telogen effluvium by multiple dermatologists, but doubts the diagnosis due to the severity and speed of the hair loss. They are considering various treatments like spironolactone, estradiol, and possibly finasteride, while also exploring the possibility of hormonal imbalances or autoimmune issues.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

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Learn

2 / 801 results

learn Biotin

supplement to help with hair texture and quality

learn unspecified lectican proteoglycans (nourkrin)

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Clinics

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