A Case Report of Inflammatory Nonscarring Alopecia Associated with the Epidermal Growth Factor Receptor Inhibitor Erlotinib

    June 2009 in “ Journal of Cutaneous Pathology ”
    Marinya Pongpudpunth, Marie France Demierre, Lynne J. Goldberg
    Studysummary This article discusses the cutaneous side effects of erlotinib, an EGFR inhibitor, in a patient with non-small cell lung cancer, reporting nonscarring alopecia and indicative scalp biopsy findings.
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    Research cited in this study 9

    1. The PRIDE Syndrome: Dermatological Side Effects of EGFR Inhibitors British Journal of Dermatology · 2006
    2. Nonscarring Inflammatory Alopecia Associated With the Epidermal Growth Factor Receptor Inhibitor Gefitinib Journal of the American Academy of Dermatology · 2006
    3. Trichomegaly of the Eyelashes Following Treatment with Cetuximab Annals of oncology · 2005
    4. Follicular and Epidermal Alterations in Patients Treated with ZD1839 (Iressa), an Inhibitor of the Epidermal Growth Factor Receptor British journal of dermatology/British journal of dermatology, Supplement · 2002
    5. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    6. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    7. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    8. Comparison of Epidermal Growth Factor Binding and Receptor Distribution in Normal Human Epidermis and Epidermal Appendages Journal of Investigative Dermatology · 1984
    9. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle Journal of Investigative Dermatology · 1984

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