Folliculitis Decalvans-Like Alopecia During EGFR Inhibitors Treatment for Lung Cancer: A Case Series of 6 Patients

    Michela Starace, Bianca Maria Piraccini, Miriam Anna Carpanese, Matilde Iorizzo, Zoe Apalla
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    TLDR Some lung cancer patients treated with EGFR inhibitors may develop a hair loss condition similar to folliculitis decalvans.
    The document presents a case series involving 6 patients who developed a condition resembling folliculitis decalvans, a rare form of scarring alopecia, while undergoing treatment with epidermal growth factor receptor (EGFR) inhibitors for lung cancer. The study suggests a potential association between the use of EGFR inhibitors and the development of this alopecia-like condition. The findings indicate that patients receiving EGFR inhibitor therapy for lung cancer may be at risk of developing hair loss conditions that mimic folliculitis decalvans, highlighting the need for awareness among clinicians to manage this potential side effect. The study's conclusions are based on the observed cases, but the small sample size suggests that further research is needed to establish a definitive link and to understand the underlying mechanisms.
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