Skin Toxicity Caused by EGFR Antagonists: An Autoinflammatory Condition Triggered by Deregulated IL-1 Signaling?

The document discussed the acneiform skin eruptions that often occurred in cancer patients due to the pharmacological inhibition of the epidermal growth factor receptor (EGFR). It explored the potential pathogenic mechanisms behind this phenomenon, particularly focusing on how EGFR blockade in keratinocytes of the hair follicle's outer root sheath might lead to deregulated interleukin (IL)-1 signaling. The study suggested that EGFR activation played a role in controlling IL-1-dependent inflammatory networks at the hair follicle, and its inhibition could trigger an autoinflammatory condition.