Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege

    March 2024 in “ International Journal of Cosmetic Science ”
    Susan L. Limbu, Talveen S. Purba, Matthew Harries … Ralf Paus
    Studysummary This study observed that dandruff-affected scalp skin has increased T-cell infiltration in the epidermis and a reduction in the hair follicle's physiological immune privilege, particularly in the suprabulbar outer root sheath area, indicating a distinct immune microenvironment compared to healthy scalp.
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    Research cited in this study 22

    1. MTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation EMBO reports · 2023
    2. Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata eLife · 2023
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    6. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
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    8. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    9. Hair Growth Control by Innate Immunocytes: Perifollicular Macrophages Revisited Experimental Dermatology · 2019
    10. Nuclear Factor (Erythroid-Derived 2)-Like-2 Pathway Modulates Substance P–Induced Human Mast Cell Activation and Degranulation in the Hair Follicle The Journal of Allergy and Clinical Immunology · 2018
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    15. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
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    19. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    20. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    21. Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege Journal of Investigative Dermatology · 2005
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    Related research 5

    1. Dandruff Is Associated With Perturbations of Hair Follicle Immune Privilege and the Infundibular and Epidermal Immune Microenvironment Journal of Investigative Dermatology · 2022
    2. TRPV3 Gain-of-Function Mutation Impairs Differentiation of Hair Follicle Inner Root Sheath ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    4. Three-Dimensional Culture of Plucked Human Hair Follicles Inside the Collagen Gel Matrix PubMed · 1990
    5. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981