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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Repurposing Existing Drugs for COVID-19: An Endocrinology Perspective

34 citations , September 2020 in “BMC Endocrine Disorders”

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

research Potential Biomolecule Fisetin: Molecular and Pharmacological Perspectives

March 2024 in “Current materials science”

Fisetin, found in fruits and vegetables, may help treat various health conditions like inflammation, diabetes, heart issues, cancer, and hair loss.

research Transcriptomic Analyses of Regenerating Adult Feathers in Chicken

45 citations , October 2015 in “BMC Genomics”

Chicken feather growth involves specific genes and shares similarities with hair development.

research Autoimmunity in Satoyoshi Disease: A Systematic Review

July 2022 in “medRxiv (Cold Spring Harbor Laboratory)”

Satoyoshi syndrome is likely an autoimmune disease that mainly affects young women and improves with immune-related treatments.

View more "ss2-microglobulin" in research →

Community Join

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community Thinning in Hairline and Vertex - What do I do?

in General 345 upvotes 4 days ago

A 25-year-old male is experiencing hair thinning at the hairline and vertex, considering using a dermapen or dermastamp, and seeking advice on whether to continue with natural remedies like onion juice and rosemary oil or start using minoxidil or finasteride. He is also looking for recommendations on microneedling devices.

community Two months of minoxidil 5mg only!

in Progress Pictures 197 upvotes 6 months ago

The conversation discusses hair loss treatments, specifically the use of minoxidil and the potential addition of finasteride. The user has seen some progress with minoxidil but is hesitant about finasteride due to possible side effects, while others suggest combining both for better long-term results.