The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling

January 2011 in “ Development ”

Silvio Weber, Michaela Niessen, Johannes Prox, Renate Lüllmann‐Rauch, Annika Schmitz, Ralf Schwanbeck, Carl P. Blobel, Ellen Jorissen, Bart De Strooper, Carien Niessen, Paul Säftig

Adam10 epidermis skin barrier sebaceous glands keratinocytes hair loss Notch signaling pathway Notch intracellular domain Notch processing epidermal hyperproliferation cytokine TSLP thymic atrophy skin hair Notch signaling TSLP

Studysummary This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.

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Research cited in this study

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