The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling

    January 2011 in “ Development ”
    Silvio Weber, Michaela Niessen, Johannes Prox … Paul Säftig
    Studysummary This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.biologists.com →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    2. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    3. Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus PLoS Genetics · 2006
    4. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    5. Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development Proceedings of the National Academy of Sciences of the United States of America · 2003
    6. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    7. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    8. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    9. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000