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GlossaryHair Follicle Stem Cells

specialized cells in hair follicles that regenerate hair and skin

Hair Follicle Stem Cells (HFSCs) are specialized cells located in the bulge region of hair follicles. They play a crucial role in the growth and regeneration of hair by periodically activating to produce new hair shafts and contribute to the repair of skin injuries. These cells have the unique ability to self-renew and differentiate into various cell types, making them essential for maintaining healthy hair and skin.

Related Terms

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learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

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Research

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research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations, April 2011 in “Science”

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations, January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

research Hair Follicle Stem Cells: Walking the Maze

165 citations, June 2007 in “European Journal of Cell Biology”

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

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Community Join

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community PP405 - hair stem cell stimulation

in Research/Science 51 upvotes 9 months ago

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

community Fun thought experiment about halting hair loss permamently

in Research/Science 58 upvotes 7 months ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

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